The Challenge
The company aimed to perform a comprehensive analysis of camelid germline immunoglobulin V gene repertoires and assess homology to human counterparts. Manual analysis of thousands of sequences is time-consuming and prone to error.
Our Approach
We mined camelid genomes, analysed homology with humans and streamlined immunoinformatics to accelerate antibody discovery.
- Genome mining & annotation: Used Antibody-extractor® to mine camel and alpaca genomes, identifying new V-gene repertoires and annotating them against human counterparts.
- Homology analysis & structural prediction: Analysed homology and predicted structures between camelid and human repertoires, confirmed with X-ray crystallography.
- Efficiency & simplification: Reduced analysis time from days to minutes and enabled discovery of two antibodies that advanced to Phase 1b studies.
The Outcome
- Simplified and accelerated antibody discovery, yielding novel biological insights.
- Revealed counterparts of all human V-gene families across camel, alpaca and llama species.
- Improved processing efficiency and produced antibodies now in clinical development.
Why It Matters
Purpose-built computational tools reduce the barriers to antibody discovery. Automating sequence analysis accelerates therapeutic development and opens new avenues in immuno-biotech.