Gene expression biomarkers in osteoarthritis

Gene expression biomarkers in osteoarthritis

The Challenge The client developed a cartilage‑on‑a‑chip technology and a gene panel to monitor treatment effects. They needed additional in vivo human evidence and comprehensive literature review to refine the panel and convince investors. Our Approach We...
In silico modeling supports fast‑tracking of market entry

In silico modeling supports fast‑tracking of market entry

The Challenge To obtain regulatory approval and accelerate market entry, Paleo needed to demonstrate that their animal‑free myoglobins are safe and to optimise production yields. Assessing immunogenicity and toxicity and modelling production processes required...
Discovering biomarkers in cerebrospinal fluid EVs

Discovering biomarkers in cerebrospinal fluid EVs

The institute wanted to identify diagnostic biomarkers for neurodegenerative diseases by analysing proteins in extracellular vesicles from cerebrospinal fluid. Shotgun proteomics data contained missing values and required rigorous processing. Our Approach We applied...
Custom pipeline for metagenomics & metabolomics data

Custom pipeline for metagenomics & metabolomics data

The Challenge The client needed a complete software suite for automated analysis and visualisation of metagenomic and metabolomic data. Existing workflows involved multiple tools and manual data transfers, limiting efficiency. Our Approach We standardised and...
Characterising inflammation using spatial transcriptomics

Characterising inflammation using spatial transcriptomics

The Challenge The client wanted to use spatial single‑cell transcriptomics to study the molecular histopathology of chronic inflammatory bowel disease. No benchmarked workflows existed, and the technology required sophisticated analysis. Our Approach We re‑annotated...